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Solid waste contaminated with infectious agents known to cause human illness and not contaminated with radioactive materials or hazardous chemicals.
In a research laboratory, this would include solid waste generated from any work with human or non-human primate blood, tissue, or cells and microbiological agents that may cause human illness. This also includes animal carcasses infected with infectious agents known to cause human illness. American National Institute of Health has created a list of microbiological agents that is categorized into 4 major risk groups.
Agents that fall within Risk Groups 2,3 and 4 are considered biohazardous and should be treated as such. Agents that fall within Risk Group 1 are considered as biowaste and do not fall under the biohazardous waste requirements although certain precautions still need to be followed.
| Classification of Biohazardous Agents by Risk Group (RG) 1) |
BS Level |
| RISK GROUP I |
Agents that are not associated with disease in healthy adult humans |
BSL-1 |
| RISK GROUP II |
Agents that are associated with human disease which is rarely serious and for which preventative or therapeutic interventions are often available |
BSL-2 |
| RISK GROUP III |
Agents that are associated with serious or lethal human disease for which preventive or therapeutic interventions may be available (high individual risk but low community risk) |
BSL-3 |
| RISK GROUP IV |
Agents that are likely to cause serious or lethal human disease for which preventive or therapeutic interventions are not usually available) (high individual risk and high community risk) |
BSL-4 |
LifeScience Park infrastructure allows to arrange labspace to Biosafety Level up to BSL-3. There is a few guidelines, that detereminates a quality of laboratory work, which is necessary in BSL-3 standard:
- Eletronical access control
- Work in certified BSC
- Separate building or isolated laboratory zone
- Double door entry
- Directional inward airflow
- Walls, floors and ceilings are water resistant for easy cleaning
- Certyfied lab equipment
Examples of Risk Group III Agents
| Bacterial Agents including Rickettsia 2) |
| Bartonella |
Brucella including z B. abortus, B. canis, B. suis |
Burkholderia (Pseudomonas) mallei, B. pseudomallei |
| Coxiella burnetii |
Francisella tularensis |
Mycobaceterium bovis (except BCG strain), Risk Group 2 – Bacterial Agents including Chlamydia), M. tuberculosis |
| Pasteurella multocida type B – “buffalo” and other virulent strains |
Rickettsia akari, R. australis, R. canada, R. conorii, R. prowazekii, R. rickettsii, R. siberica, R. tsutsugamushi, R. typhi (R. mooseri) |
Yersinia pestis |
| Fungal Agents |
| Coccidioides immitis (sporulating cultures; contaminated soil |
Histoplasma capsulatum, H. capsulatum var. duboisii |
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| Parasitic Agents |
| - |
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| Viruses and Prions |
Aphaviruses (Togaviruses) – Group A Arboviruses
- Semliki Forest virus
- St. Louis encephalitis virus
- Venezuelan equine encephalomyelitis virus (except the vacine strain TC-83, RG2) |
Arenaviruses
- Flexal
- Lymphocytic choriomeningitis virus (LCM) (neurotropic strains) |
Flaviviruses (Togaviruses) – Group B Arboviruses
- Japanese enchephalitis virus
- Yellow fever virus |
Poxviruses
- Monkeypox virus |
Prions
- Transmissible spongioform encephalopathies (TME) agents (Creutzfeldt-Jacob disease and kuru agents) |
Retroviruses
- Human immunodeficiency virus (HIV) types 1 and 2
- Human T cell lymphotropic virus (HTLV) types 1 and 2
- Simian immunodeficiency virus (SIV) |
Rhabdoviruses
- Vesicular stomatitis virus |
1)NIH Guidelines for Research Involving Recombinant DNA Molecules, May 1999
2)Richmond, JY and RW McKinney, 1993: Biosafety in Microbiological and Biomedical Laboratories. US Department of Health and Human Services, CDC/NIH, 3rd Edition. US Government Printing Office, Washington, DC.
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LABSPACE FOR LEASE 
